IL23R haplotypes provide a large population attributable risk for Crohnʼs disease
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چکیده
منابع مشابه
IL23R haplotypes provide a large population attributable risk for Crohn's disease.
BACKGROUND The IL-23 pathway plays a pivotal role in the development of chronic mucosal inflammation seen in the inflammatory bowel diseases. Multiple studies have now established the contribution of the interleukin 23 receptor gene (IL23R) to Crohn's disease (CD) risk in general and of the IL23R R381Q variant in particular. The aim of this work was to estimate the total contribution of this ge...
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DNA samples from 339 Crohn's disease (CD) and 407 randomly selected controls from the Auckland (New Zealand) IBD project, were genotyped for five common single nucleotide polymorphisms in IL-23R (rs11805303, rs7517847, rs1343151, rs11209026, and rs10889677) and two in IL-12B (rs1363670 and rs6887695). While the IL-12B variants did not show an overall association and other IL23R variants led to ...
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ژورنال
عنوان ژورنال: Inflammatory Bowel Diseases
سال: 2008
ISSN: 1078-0998
DOI: 10.1002/ibd.20478